Description

The course covers drugs used for treatment of urinary tract infections, otitis media and infectious bronchitis and sinusitis, and community acquired pneumonia. It also includes drugs used to manage meningitis, infective endocarditis, osteomyelitis and diabetic foot infections, sepsis and septic shock, tuberculosis, and opportunistic infections in AIDS patients. Drugs for Herpes virus infections and for viral hepatitis are also presented. The drugs are discussed relevant to their possible structure – activity relationships, contraindications, prodrug and bioactivation concepts, if any, and their possible metabolism and elimination.

Program

PharmD Clinical

Objectives

• -Intended Learning Outcomes By the end of the course students will be able to: a. Knowledge and Understanding a.1. Recognize the chemical structure, pharmacophore moieties and structure activity relationships in each class of the drugs used in the above-mentioned disorders. a.2. Explain the relationship between chemical structure and pharmacodynamics & pharmacokinetics in each drug class. a.3. Discuss the process of drug design, synthesis, and metabolism in certain classes of the studied drugs. a.4. State the side effects and uses of the studied drugs in relation to their structure. a.5. Describe the principle of structure-based drug design (SBDD) strategies of drug-receptor interactions through computer-aided drug design. b. Intellectual Skills b.1. Relate the concepts of drug receptor interactions to their activity. b.2. Predict the biological response of some drugs and medical use by referring to their chemical structures. b.3. Modify a compound structure to alter its physicochemical properties. b.4. Suggest the suitable route of administration of different drugs according to their chemical features. c. Professional and Practical Skills c.1. Examine a drug structure to deduce relative receptor affinity, metabolic pathways, distribution potential, and potential side effects or toxicities based on functional group properties and structural similarity to other pharmacophores. c.2. Design new chemical entities of drugs with improved biological activity based on computer aided drug design (in silico docking protocols). c.3. Perform suitable analytical methods for the assay of an active ingredient in a bulk or a single component. d. General and Transferable Skills d.1. Develop self-learning abilities via answering simple research questions. d.2. Interact efficiently with others.