Description

The course introduces the aspects of mammalian biochemistry and metabolism. It discusses the biochemical processes pertinent to carbohydrates, lipids, proteins, and nucleotides, as well as any related abnormalities and potential sites for medication action. The scientific basis of these processes is provided at the molecular level enabling the students to begin to understand the pathophysiological basis of metabolic disorders. ATP synthesis from reduced metabolites (electron transport chain- inhibitors- uncouplers). Regulation of blood glucose level and clinical correlations, Inborn errors of metabolism, Second messengers and signal transduction. Biochemistry of cancer and oxidative stress and body defense mechanisms.

Program

PharmD Clinical

Objectives

• By the end of the course students will be able to: a. Knowledge and Understanding a.1. Recall the role of ATP generation, citric acid cycle reactions and mitochondrial oxidative phosphorylation. a.2. Explain the metabolic steps involved in energy transduction inside the cell. a.3. Explain basic knowledge required to understand the mechanism of action of some drugs. a.4. Understand the pathophysiological basis of metabolic disorders b. Intellectual Skills b.1. Interpret laboratory data. b.2. Correlate biochemical abnormalities in carbohydrate, lipid, protein and nucleotide metabolism to potential sites for medication action. c. Professional and Practical Skills c.1. Perform biochemical techniques used professionally in research and clinical laboratories. c.2. Integrate biochemical knowledge and clinical aspects to solve clinical problems d. General and Transferable Skills d.1. Use internet information and tools to access, organize and deliver necessary information d.2. Critical appraisal of available information. d.3. Work in groups collaboratively on related topics