Description

The course deals with clinical pharmacokinetics and its applications. Topics include pharmacokinetics, drug distribution and drug clearance mechanisms, IV infusion kinetics and kinetics following extra-vascular dosing, metabolite kinetics, multiple dose kinetics, non-linear pharmacokinetics, dosage regimen design, dosage individualization of drugs of narrow therapeutic index especially in patients with compromised renal and hepatic function.

Program

PharmD Clinical

Objectives

• Intended Learning Outcomes By the end of the course students will be able to: a. Knowledge and Understanding a.1. Define therapeutic drug monitoring (TDM) and identify its application in hospital setting a.2. Recognize the general pharmacokinetics in special populations a.3. Describe the general pharmacokinetic properties of some selected drugs a.4. Determine the effect of renal and hepatic impairment on drug pharmacokinetics b. Intellectual Skills b.1. Calculate the elimination half-life, elimination rate constant, absorption rate constant, apparent volume of distribution, and total body clearance from the population pharmacokinetics data b.2. Monitor the proper pharmacokinetic and pharmacodynamic parameters for a specific patient b.3. Modify the therapeutic regimen based on the efficiency of the renal and liver elimination of the drug c. Professional and Practical Skills c.1. Identify factors that affect the absorption, distribution, metabolism, excretion, and binding of drugs c.2. Apply pharmacokinetic concepts in order to determine an individualized dosage regimen for a specific patient d. General and Transferable Skills d.1. Apply problem solving skills and critical thinking to reach proper pharmaceutical decisions