Description

The course covers drugs used for bacterial infections, Urinary tract infections, otitis media and infectious bronchitis and sinusitis, community acquired pneumonia. Drugs used to manage meningitis, infections of endocarditis, osteomyelitis and diabetic foot infections, sepsis and septic shock, tuberculosis. Drugs for opportunistic infections in AIDS patients. drugs for Herpes virus infections and for viral hepatitis are also presented. The drugs are discussed relevant to their possible structure – activity relationships, contraindications, prodrug and bioactivation concepts, if any, their possible metabolism and elimination.

Program

PharmD

Objectives

• Domain (1): Fundamental knowledge By the end of the course the student should be able to: 1.1 Recognize the chemical structure, pharmacophore moieties and structure activity relationships in each class of the drugs used in the infectious disorders. 1.2 Explain different physicochemical properties based on chemical structure of the antimicrobial drugs 1.3 Evaluate the effect of different pharmacokinetic properties on the drug effectiveness and safety in different clinical settings. 1.4 Discuss the process of drug design and, synthesis in certain classes of the studied drugs. 1.5 Describe the principle of structure-based drug design (SBDD) strategies of drug-receptor interactions through computer-aided drug design. Domain (2): Professional and Ethical Practice At the end of the course the student should be able to: 2.1 Design new chemical entities of drugs with improved biological activity based on computer aided drug design techniques (in silico docking protocols). 2.2 Carry out suitable analytical methods for the assay of active ingredients in a bulk or a single component. 2.3 Fulfil the requirements of the regulatory framework to authorize a medicinal product including quality, safety, and efficacy requirements. Domain (3): Pharmaceutical Care At the end of the course the student should be able to: 3.1 Integrate the pharmacological properties of antimicrobial drugs including mechanisms of action, therapeutic uses, dosage, contra-indications, adverse drug reactions and drug interactions. Domain (4): Personal Practice At the end of the course the student should be able to: 4.1 Demonstrate responsibility for team performance and peer evaluation of other team members, and express time management skills. 4.2 Retrieve and critically analyze information, identify and solve problems, and work autonomously and effectively in a team. 4.3 Use new technologies and media to demonstrate effective presentation skills. 4.4 Practice self-learning needed for continuous professional development.