Medicinal Chemistry I (1 hr Lecture+1 hr Practical)

  • College of Pharmacy |

Description

This course covers the different approved methods of naming drug molecules. The process of drug discovery and development is high lightened. It comprises an introduction to the physiochemical properties of drugs relative to their biological effects. The students are exposed to the concepts of structure-activity relationships and drug-receptor interactions. Highlights and a quick review of modern screening and modeling operations are also explained. The student is exposed to the concept of bio-isosterism and its application in designing new drugs. The course also covers drugs used in hepatic disorders including viral hepatitis, pancreatitis, gastrointestinal bleeding, peptic ulcer, gastro-esophageal reflux disease, inflammatory bowel diseases and irritable bowel syndrome as well as gastrointestinal symptoms including nausea, vomiting, constipation, and diarrhea.

Program

PharmD

Objectives

  • Domain (1): Fundamental knowledge By the end of the course the student should be able to: 1.1 Demonstrate the discovery, classification and nomenclature of drugs. 1.2 Integrate the effect of physicochemical properties on drugs absorption, distribution, metabolism and elimination of the drug. 1.3 Identify drug-receptor interactions and methods for optimization of these interactions. Domain (2): Professional and Ethical Practice At the end of the course the student should be able to: 2.1 Design different optimization strategies of physicochemical properties including the use of physicochemical descriptors. 2.2. Identify structure activity relationship of GIT, hepatitis and pancreatitis drugs. 2.3 Recognize the concept of isomers, isosterism and bioisosterism. Domain (3): Pharmaceutical Care At the end of the course the student should be able to: 3.1 Apply different research tools to identify different mechanisms of action. 3.2 Integrate drug design software and its applications. Domain (4): Personal Practice At the end of the course the student should be able to: 4.1 Demonstrate responsibility for team performance and peer evaluation of other team members, and express time management skills. 4.2 Retrieve and critically analyze information, identify and solve problems, and work autonomously and effectively in a team. 4.3 Use new technologies and media to demonstrate effective presentation skills. 4.4 Practice independent learning needed for continuous professional development

Textbook

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Course Content

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