Basic pharmacology (2 hrs Lecture+1 hr Practical)

  • College of Pharmacy |

Description

This course provides the students with the knowledge of the basic principles of pharmacology, pharmacodynamics (general and molecular aspects) and pharmacokinetics. Concepts of agonism, antagonism, and modulation of receptor activity are reviewed together with a general overview of the different potential interventions with the function of various neurotransmitters and humoral mediators as examples of mechanisms of drug action. Practical exercises aim to help students apply this acquired knowledge using selected in-vitro animal models as well as simulation techniques.

Program

Bachelor of Pharmacy - PharmD (Clinical Pharmacy)

Objectives

  • 1.1

    Explain the processes and basic parameters of drug absorption, distribution, metabolism, and excretion.

    1.2

    Interpret dose-response curves and distinguish agonism, antagonism, potency, and efficacy.

    1.3

    Explain the principal neurotransmitters and pharmacological control of the autonomic nervous system.

    2.1

    Calculate basic pharmacokinetic parameters from provided data.

    2.2

    Apply pharmacokinetic principles in simulation models and simple dosage-regimen problems.

    2.3

    Perform pharmacology laboratory activities safely and ethically, following approved procedures for handling and disposal of biological and pharmaceutical materials.

    3.1

    Relate pharmacokinetic and pharmacodynamic principles to the safe and rational use of medicines.

    3.2

    Explain how mechanisms of action, contraindications, adverse drug reactions, and drug interactions influence medicine use.

    3.3

    Identify common adverse drug reactions and propose appropriate monitoring measures in basic cases.

    4.1

    Analyze basic pharmacological cases using critical-thinking and problem-solving skills.

    4.2

    Communicate pharmacological information clearly in written and oral formats.

    4.3

    Work effectively and responsibly as a member of a team during practical activities.

    4.4

    Demonstrate self-directed learning by locating and using appropriate scientific resources for continuous professional development.

Textbook

Rang, H. P., Dale, M. M., Ritter, J. M., Flower, R. J., & Henderson, G. (2016). Rang and Dale's Pharmacology (8th ed.). Elsevier Churchill Livingstone. Brunton, L. L. (Ed.). (2011). Goodman & Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw-Hill; course lecture and tutorial notes.

Course Content

content serial Description
1Introduction to pharmacology (Lecture)
1Introduction to the pharmacology lab and types of experiments (Practical)
2Pharmacodynamics: general aspects (Lecture)
2Autonomic NS Introduction and concept of NT and OBSIM (Practical)
3Pharmacodynamics: molecular aspects (1) (Lecture)
3Different types of receptors (Practical)
4Pharmacodynamics: molecular aspects (2) (Lecture)
4Dose response curve on different drugs and measuring parameters (Practical)
5Pharmacokinetics: introduction (Lecture)
5Pharmacokinetics (Practical)
6Pharmacokinetics: absorption and distribution (Lecture)
6Autonomic nervous system disorders dysautonomia (Practical)
7Pharmacokinetics: metabolism and excretion (Lecture)
7Quiz (Practical)
8Autonomic nervous system pharmacology (1) (Lecture)
8Effect of indirectly acting stimulant drugs on isolated rabbit intestine (acetylcholine) (Practical)
9Autonomic nervous system pharmacology (2) (Lecture)
9Effect of indirectly acting stimulant drugs on isolated rabbit intestine (acetylcholine) (Practical)
10Parasympathetic pharmacology (1) (Lecture)
10Reversible competitive of atropine and acetylcholine drugs on isolated rabbit intestine (acetylcholine/atropine) (Practical)
11Parasympathetic pharmacology (2) (Lecture)
11Effect of directly acting stimulant drugs on isolated rabbit intestine (Barium chloride) (Practical)
12Parasympathetic pharmacology (3) (Lecture)
12Differentiate between the effect of directly and indirectly acting drugs on isolated rabbit intestine (Practical)
13Sympathetic pharmacology (1) (Lecture)
13Practical Quiz of unknown (Practical)
14Sympathetic pharmacology (2) (Lecture)
14Kortext open book activity on uncovered topics (Practical)
15Sympathetic pharmacology (3) (Lecture)

Markets and Career

  • Generation, transmission, distribution and utilization of electrical power for public and private sectors to secure both continuous and emergency demands.
  • Electrical power feeding for civil and military marine and aviation utilities.
  • Electrical works in construction engineering.

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