Excellence in Scientific Research

Excellence in scientific research 

Excellence in scientific research is a crucial facet of advancing our understanding of the world around us. It is through rigorous and meticulous research that we are able to unravel mysteries and solve complex problems. Scientists who strive for excellence in their work hold themselves to the highest standards, ensuring that their methodologies are robust and their findings are accurate and reliable.

Achieving excellence in scientific research requires a combination of intellectual curiosity, dedication, and a commitment to the pursuit of knowledge. Scientists must possess a deep passion for their field of study, constantly seeking new ideas and innovative approaches to expand the boundaries of human understanding. They must be willing to invest countless hours in the laboratory, engaging in meticulous experimentation and analysis to uncover meaningful results.

Moreover, excellence in scientific research goes beyond individual achievements. Collaboration and teamwork play a crucial role in fostering excellence, as scientists often work together to tackle complex problems that require diverse expertise. Sharing knowledge, ideas, and resources enables researchers to build upon each other's work, pushing the boundaries of scientific discovery even further. Ultimately, excellence in scientific research not only advances our understanding but also has the potential to drive innovation, improve human lives, and shape the future of our society.

2024

•Dr. Nermeen Hisham Kamal Eldin, Assistant Lecturer in the Department of Pharmaceutical Sciences, specializing in Pharmaceutics, has been awarded second place in the poster competition at the Controlled Release Society Annual Meeting and Exposition (CRS 2024), held from July 8 to 12 in Bologna, Italy. Her awarded research was titled "The Bone Regenerative Potential of Various Quercetin Loaded Lipid Nano-formulations Loaded in Biodegradable Calcium Phosphate Cement Scaffolds." 

• Under the guidance of His Excellency Prof. Dr. Ismail Abdel Ghaffar Ismail Farag, President of the Arab Academy for Science, Technology, and Maritime Transport. the College of Pharmacy participated in the 5th Arab Water Conference, hosted by Riyadh, Saudi Arabia. The event was organized by the Ministry of Environment. Water, and Agriculture in coordination with the Technical Secretariat of the Arab Ministerial Water Council at the League of Arab States, held from November 22-23, 2023. 
Dr. Miran Ahmed Al-Haggar, a researcher at the College of Pharmacy's Research Center at the Academy's main headquarters, participated in a special session on the value of water and the circular economy. She presented a research paper titled "The Effective Impact of Plants in Water Recycling for Achieving Environmental Sustainability and Enhancing the Circular Economy," which was accepted by the conference's scientific committee. 

• Dr. Mariam Mohamed Shamma, Head of Clinical and Biological Sciences Departments and Assistant Professor of Biochemistry and Molecular Biology at the College of Pharmacy, represented the College of Pharmacy, Arab Academy for Science, Technology, and Maritime Transport at the 48th FEBS Congress 2024. She presented her research as an oral presentation, which had been accepted for publication by the conference's scientific committee on behalf of the College of Pharmacy, Arab Academy for Science, Technology, and Maritime Transport. The research was titled: "Diosmin synergistically potentiates the anti-tumor effects of regorafenib against HCC via dual inhibition of Pl3K/mTOR and RAS/Erk signaling pathways." Her presentation received significant and notable praise from the examining committee and professors from around the world. 

• Dr. Mohamed EI-Khouly attended the ASM Microbe 2024 conference, where he delivered a lecture titled "Characterization of a Large Collection of Clinical Yeast Isolates from Alexandria, Egypt." This presentation was a significant outcome of an international collaboration with a team from Radboud University in the Netherlands. The project focused on the detailed characterization of clinical yeast isolates, contributing valuable insights into microbial diversity and resistance patterns in the Alexandria region. 

• A delegation from the College of Pharmacy at the Arab Academy for Science, Technology, and Maritime Transport participated in the 6th International Conference on Pharmaceutical Sciences, held at Future University in Cairo from February 14-15. 

 

List of publications 

Gayed, M., Gaber, D. M., & Borae, N. Development and Evaluation of Lipid-Based Formulations for Liver Cancer: A Comparative Study of Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers. International Journal of Theoretical and Applied Nanotechnology, 2023, 11, 01-08. doi: 10.11159/ijtan.2023.001
AGE Sarah K. Amer, Hany Eldeeb, Pharmaceutical and Clinical Assessment of Multi-source Tegretol® Sold In Egypt. International Journal of Pharmaceutical Quality Assurance. 2023, 14 (3), 675-686
Spruijtenburg B, Meijer EFJ, Xiao M, Shawky SM, Meis JF, de Groot T, El-Kholy MA. Genotyping and susceptibility testing uncovers large azole-resistant Candida tropicalis clade in Alexandria, Egypt. J Glob Antimicrob Resist. 2023 Sep;34:99-105. doi: 10.1016/j.jgar.2023.06.012.
Werida, R., Ramzy, A., Ebrahim, Y., Helmy, M. (2024). 'Role of Omega-3 Polyunsaturated Fatty Acid Supplementation in Patients with Type 2 Diabetes Mellitus', Journal of Advanced Medical and Pharmaceutical Research, 5(1), pp. 8-14. doi: 10.21608/jampr.2023.235466.1058
Christina A. Lamey, Nermine Moussa, Maged W. Helmy, Medhat Haroun, Sally A. Sabra, Simultaneous encapsulation of dasatinib and celecoxib into caseinate micelles towards improved in vivo anti-breast cancer efficacy with reduced drug toxicity, Journal of Drug Delivery Science and Technology, Volume 87,2023, 104807, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2023.104807.
Dina M. Gaber, Noha Nafee, Ahmed O. Elzoghby et al. In vivo pharmacodynamics of lactoferrin-coupled lipid nanocarriers for lung carcinoma: intravenous versus powder for inhalation, 17 October 2023, PREPRINT (Version 1) available at Research Square (preprint) https://doi.org/10.21203/rs.3.rs-3334664/v1
Fayad E, Altalhi SA, Abualnaja MM, Alrohaimi AH, Elsaid FG, Abu Almaaty AH, Saleem RM, Bazuhair MA, Ahmed Maghrabi AH, Beshay BY, Zaki I. Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues. ACS Omega. 2023 Oct 9;8(41):38394-38405. doi: 10.1021/acsomega.3c05051.
Fawzy SM, Loksha YM, El-Sadek M, Ibrahim SM, Beshay BY, Shamaa MM, Kothayer H. Synthesis of 1,2,4-triazole and 1,3,4-oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer. Arch Pharm (Weinheim). 2023 Nov;356(11):e2300345. doi: 10.1002/ardp.202300345.
Kamal MF, Youssef RM, Morshedy S, El-Sayed NW. Green and Smart Quantitative Quality Control for Veterinary Mixture of Ivermectin and Clorsulon: Ecological Evaluation of Spectral Analyses via Analytical Eco-Scale, Green Analytical Procedure Index, and Analytical GREEnness Metric Approaches. J AOAC Int. 2023 Nov 2;106(6):1455-1463. doi: 10.1093/jaoacint/qsad098. 
Abd El-Lateef HM, Abdel Ghany LMA, Saleem RM, Ahmed Maghrabi AH, Yahya Alahdal MA, Khalifa Ali EH, Beshay BY, Zaki I, Masoud RE. Design, synthesis and antiproliferative screening of newly synthesized coumarin-acrylamide hybrids as potential cytotoxic and apoptosis inducing agents. RSC Adv. 2023 Nov 6;13(46):32547-32557. doi: 10.1039/d3ra06644d. 
Werida RH, Ramzy A, Ebrahim YN, Helmy MW. Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial. BMC Endocr Disord. 2023 Nov 25;23(1):259. doi: 10.1186/s12902-023-01511-2. 
El-Kholy MA, Helaly GF, El Ghazzawi EF, El-Sawaf G, Shawky SM. Analysis of CDR1 and MDR1 Gene Expression and ERG11 Substitutions in Clinical Candida tropicalis Isolates from Alexandria, Egypt. Braz J Microbiol. 2023 Dec;54(4):2609-2615. doi: 10.1007/s42770-023-01106-y. 
Dalia M. Rasheed, Mohamed A. Farag, Amira R. Khattab, Mohamed F. Abdel Rahman, Alaadin E. El-Haddad, A comparative MS-based metabolomics study and in-vitro antidiabetic assay of galangals, turmeric and ginger aided by molecular networking and chemometrics, Industrial Crops and Products, 205, 2023, 117438, https://doi.org/10.1016/j.indcrop.2023.117438.
El Banna, Y., Abo Ayana, R., Nasr, M., Helmy, M. (2023). 'PD-1/PD-L1 AXIS INHIBITORS AS PROMISING STRATEGY FOR MANAGEMENT OF HEPATOCELLULAR CARCINOMA: EXPECTATIONS, BOUNDARIES AND PITFALLS', Journal of the Medical Research Institute, 44(2), pp. 1-8. doi: 10.21608/jmalexu.2023.323222
Ghany LMAA, Beshay BY, Youssef Moustafa AM, Maghrabi AHA, Ali EHK, Saleem RM, Zaki I, Ryad N. Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2243551. doi: 10.1080/14756366.2023.2243551.
Zakaria MY, Abd El-Halim SM, Beshay BY, Zaki I, Abourehab MAS. 'Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity': in-vitro and insilico studies. Drug Deliv. 2023 Dec;30(1):2162157. doi: 10.1080/10717544.2022.2162157
Sánchez-Urtaza S, Ocampo-Sosa A, Rodríguez-Grande J, El-Kholy MA, Shawky SM, Alkorta I, Gallego L. Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt. Front Cell Infect Microbiol. 2024 Jan 9;13:1332736. doi: 10.3389/fcimb.2023.1332736. 
Berhe HG, Birhan YS, Beshay BY, Habib HJ, Hymete A, Bekhit AA. Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives. BMC Chem. 2024 Jan 8;18(1):9. doi: 10.1186/s13065-023-01111-0. 
Mahrous, R., Fathy, H., Abu EL-Khair, R., Omar, A., & Ibrahim, R. (2024). Molecular docking and pharmacophore modelling; A bridged explanation with emphasis on validation. Journal of Advanced Pharmaceutical Sciences, 1(1), 138-152. doi: 10.21608/japs.2024.253925.1007
Hegazi N, Khattab AR, Saad HH, Abib B, Farag MA. A multiplex metabolomic approach for quality control of Spirulina supplement and its allied microalgae (Amphora & Chlorella) assisted by chemometrics and molecular networking. Sci Rep. 2024 Feb 2;14(1):2809. doi: 10.1038/s41598-024-53219-5. PMID: 38307932; PMCID: PMC10837195.
Gaber DM, Ibrahim SS, Awaad AK, Shahine YM, Elmallah S, Barakat HS, Khamis NI. A drug repurposing approach of Atorvastatin calcium for its antiproliferative activity for effective treatment of breast cancer: In vitro and in vivo assessment. Int J Pharm X. 2024 Apr 20;7:100249. doi: 10.1016/j.ijpx.2024.100249. 
Nafee N, Gaber DM, Abouelfetouh A, Alseqely M, Empting M, Schneider M. Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road? Int J Nanomedicine. 2024 Apr 29;19:3861-3890. doi: 10.2147/IJN.S445955.
M E Gaafar P, Farid RM, Hazzah HA, AbouKilila HY, Helmy MW, Abdallah OY. Magnetic Lipid-Based hybrid nanosystems: A combined stimuli- responsive nanocarriers for enriched chemotherapeutic potential of L-carnosine in induced breast Ehrlich ascites tumor model. Int J Pharm. 2024 Apr 25;655:124000. doi: 10.1016/j.ijpharm.2024.124000. 
Hassan H, Kamr A, El-Gendy AN, et al. Clinicobiochemical and GC-MS Based Serum Metabolomics for determination of Therapeutic Efficacy of Silymarin in Pneumonic Sheep. Research Square (Preprint); 2024. DOI: 10.21203/rs.3.rs-4344803/v1.
Ramadan, A., Shawky, S., Ibrahem, A., & El-Kholy, M. (2024). Experience of an Egyptian tertiary Laboratory in the diagnosis of tuberculous and non-tuberculous Mycobacterial Infections: A five-year retrospective study. Microbes and Infectious Diseases, 5(3), 948-960. doi: 10.21608/mid.2024.287718.1933
Farag MA, Khattab AR, Farghal HH, Ismail WM, Fahmy HA. Gas chromatography/mass spectrometry-based metabolite profiling of chia and quinoa seeds in comparison with wheat and oat. Phytochem Anal. 2024 May 27. doi: 10.1002/pca.3398. Epub ahead of print. PMID: 38802070.
Marey MA, Abozahra R, El-Nikhely NA, Kamal MF, Abdelhamid SM, El-Kholy MA. Transforming microbial pigment into therapeutic revelation: extraction and characterization of pyocyanin from Pseudomonas aeruginosa and its therapeutic potential as an antibacterial and anticancer agent. Microb Cell Fact. 2024 Jun 13;23(1):174. doi: 10.1186/s12934-024-02438-6.
Nehal W. El-Sayed, Rasha M. Youssef, Samir Morshedy, Miranda F. Kamal, Greenness appraisal and development of validated spectrophotometric methods for assay of amprolium: Comparative study using Analytical Eco-Scale, GAPI, and AGREEmetric approaches, Green Analytical Chemistry, 9, 2024, 100107, https://doi.org/10.1016/j.greeac.2024.100107.
Kamal MF, Youssef RM, El-Sayed NW, Morshedy S, Elbordiny HS. Penalization and Color Code-Technical Approaches for Methods' Greenness and Whiteness Appraisal in Veterinary Medication: Assay of Toltrazuril Suspension. J AOAC Int. 2024 Jul 18:qsae063. doi: 10.1093/jaoacint/qsae063.
Moussa AY, Abbas H, Zewail M, Gaafar PME, Ibrahim N. Green preparation and evaluation of the anti-psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo-cosmetic lead. Arch Pharm (Weinheim). 2024 Aug 23:e2400410. doi: 10.1002/ardp.202400410.
Lina M.A. Abdel Ghany, Noha Ryad, Mohamed S. Abdel-Aziz, Hany M. Abd El-Lateef, Islam Zaki, Botros Y. Beshay, Design, synthesis, antimicrobial evaluation, and molecular modeling of new sulfamethoxazole and trimethoprim analogs as potential DHPS/DHFR inhibitors, Journal of Molecular Structure, 1309, 2024, 138170, https://doi.org/10.1016/j.molstruc.2024.138170

 

2023

- Three faculty members of the college got the opportunity to travel abroad in order to exchange experiences in order to learn about the latest research, educational and training systems followed in those universities for periods ranging from one to three months:

•Dr. Dina Mohamed Gaber Abdel Hamid, a lecturer in the Department of Pharmaceutical sciences at the college of Pharmacy, obtained a short-term scientific mission leave for a period of five weeks, due to her invitation from Saarland University in Germany to participate in scientific research, from 23/8/2022 to 30/9/2022.
•Dr. Mohamed Abdel Karim Abdel Mohsen El-Khouly, Microbiology lecturer in the department of clinical and biological sciences, received a funded training opportunity grant at Canisius-Wilhelmina Ziekenhuis, Nijmegen, Netherlands Hospital (CWZ) in the Netherlands during October 2022.
•Dr. Salma Ali Fouad Al-Mallah, Lecturer of Pharmaceutical Chemistry at the Department of Pharmaceutical Sciences at the Faculty of Pharmacy, obtained a scientific mission leave for a period of three months, due to her invitation from Queen's University in Canada to participate in scientific research, from 22/6/2023 to 27/9/2023.

- The participation of Dr. Dalia Yahya in the training on capacity building (Resource mobilization) organized by (ASAF) African students Alumni Forum under the auspices of Erasmus plus from 16 to 18.9. 2023 in Tunis.

 

 

List of publications 

Elsheikh MA, Gaafar PME, Khattab MA, A Helwah MK, Noureldin MH, Abbas H. Dual-effects of caffeinated hyalurosomes as a nano-cosmeceutical gel counteracting UV-induced skin ageing. Int J Pharm X. 2023 Feb 10;5:100170. doi: 10.1016/j.ijpx.2023.100170.
Abo Elmaaty A, Al-Karmalawy AA, Nafie MS, Shamaa MM, Zaki I, Alnajjar R, Zakaria MY. Experimental design of D-α-tocopherol polyethylene glycol 1000 succinate stabilized bile salt based Nano-vesicles for improved cytotoxicity and bioavailability of colchicine binding site inhibitor Candidates: In Vitro, in silico, and pharmacokinetic studies. Int J Pharm. 2023 Jun 10;640:122980. doi: 10.1016/j.ijpharm.2023.122980.
Salama BM, Helmy MW, Fouad H, Shamaa MM, Houssen ME. The Synergistic Antitumor Effect of Decitabine and Vorinostat Combination on HepG2 Human Hepatocellular Carcinoma Cell Line via Epigenetic Modulation of Autophagy-Apoptosis Molecular Crosstalk. Curr Issues Mol Biol. 2023 Jul 16;45(7):5935-5949. doi: 10.3390/cimb45070375. 
El-Nahas AE, Elbedaiwy HM, Masoud IM, Aly RG, Helmy MW, El-Kamel AH. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. Eur J Pharm Biopharm. 2023 Jul;188:182-200. doi: 10.1016/j.ejpb.2023.04.008. 
Sánchez-Urtaza S, Ocampo-Sosa A, Molins-Bengoetxea A, El-Kholy MA, Hernandez M, Abad D, Shawky SM, Alkorta I, Gallego L. Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt. Front Cell Infect Microbiol. 2023 Jul 20;13:1208046. doi: 10.3389/fcimb.2023.1208046.
Sánchez-Urtaza S, Ocampo-Sosa A, Molins-Bengoetxea A, Rodríguez-Grande J, El-Kholy MA, Hernandez M, Abad D, Shawky SM, Alkorta I, Gallego L. Co-Existence of blaNDM-1, blaOXA-23, blaOXA-64, blaPER-7 and blaADC-57 in a Clinical Isolate of Acinetobacter baumannii from Alexandria, Egypt. Int J Mol Sci. 2023 Aug 7;24(15):12515. doi: 10.3390/ijms241512515. 
Nawraj Rummun, Amira R. Khattab, Theeshan Bahorun, Mohamed A. Farag, Vidushi S. Neergheen, Biochemometric approach to reveal Terminalia bentzoe cytotoxic effect against HepG2 cells in relation to its different organs and extraction solvents as analysed via UPLC-MS, South African Journal of Botany, 159, 2023, 507-518, https://doi.org/10.1016/j.sajb.2023.06.037.
Dina M. Gaber, Mina Gayed, Nabila Borae, Formulation, Optimization, and Invitro Characterization of Lipid-Based Nanoparticles for Effective Delivery to the Liver, Proceedings of the 9th World Congress on New Technologies (NewTech'23) Brunel University, London, United Kingdom - August 09-11, 2023 Paper No. ICNFA 107 DOI: 10.11159/icnfa23.107