Description
In this course, a general overview of the mechanisms of drug-induced toxicity is provided. Signs and symptoms of toxicity of commonly used drugs, environmental pollutants, food-additives, household chemicals are discussed together with the proper management whether by supportive measures or with specific antidotes. Students are also introduced to the design and interpretation of pre-clinical toxicity screening tests required for approval of drug use in humans.
Program
Bachelor of Pharmacy-B Pharm
Objectives
- Overall Course Objectives
In this course, a general overview of the mechanisms of drug-induced toxicity is provided. Signs and symptoms of toxicity of commonly used drugs, environmental pollutants, food-additives, household chemicals are discussed together with the proper management whether by supportive measures or with specific antidotes. Students are also introduced to the design and interpretation of pre-clinical toxicity screening tests required for approval of drug use in humans.
Intended Learning Outcomes
By the end of the course students will be able to:
a. Knowledge and Understanding
a.1. Recognize the concept of toxicity of xenobiotics, modifying factors, and antidotal measures.
a.2. Define various organ toxicity profiles including the identification, symptoms, management and antidotal measures for toxicity of drugs, gases, heavy metals and poisons of plant and animal origin.
a.3. Recognize hazards of genetic toxicology and occupational toxicity and other selective toxicities such as toxic warfare agents, pesticides and food-borne illnesses.
a.4. Describe different preclinical testing of new drugs’ toxicity and adverse effects
b. Intellectual Skills
b.1. Differentiate toxicity symptoms, categorize toxic agents and treatment measures
b.2. Predict short and long-term health hazards of pollutants and toxins
b.3. Appraise the design of pre-clinical toxicity screening tests required for approval of drug use in humans
c. Professional and Practical Skills
c.1. Revise drug toxicities profiles and gross symptoms of poisoning
c.2. Practice identification of poisons
d. General and Transferable Skills
d.1. Communicate clearly by verbal and written means
d.2. Practice self-learning and scientific reporting
d.3. Develop time management skills to effectively manage toxicity cases
