Pre-formulation strategies and Pharmaceutical incompatibilities (2 hrs Lecture+2 hrs Practical)

Description

This course is built to confer an adequate background of pre-formulation strategies, polymorphism, and in vitro drug interactions ensuring product safety and dosing accuracy. Concepts of formulation testing and pilot manufacturing are discussed. Exercises of increasing difficulty are used to train the students to recognize and plan for potential problems pertaining to the appearance, stability, or performance of a given formulation.

Program

Bachelor of Pharmacy-B Pharm

Objectives

• a. Knowledge and Understanding a.1. Define pre-formulation and the main parameters affected by the possible interactions with the various dosage form components. a.2. Recognize the various parameters as dissolution rate, polymorphic form, crystal size, shape and habit which will affect drug physical and chemical stability. a.3. Identify the phenomena of polymorphism with an emphasis on its effect on drug safety and dosing accuracy. a.4. List the various types of excipients and additives used in the preparation of various dosage forms, the possible interactions with drugs and their effect on dosage form dissolution and stability. b. Intellectual Skills b.1. Examine the methods that could be applied for determining the drug physical and chemical stability. b.2. Differentiate between the types of excipients and additives used in the preparation of various dosage forms. b.3. Analyze laws related to the dissolution and stability of dosage forms c. Professional and Practical Skills c.1. Separate different polymorphic forms of the drug and method of testing each. c.2. Detect various types of incompatibilities during the development of different pharmaceutical preparations d. General and Transferable Skills d.1. Communicate effectively during interactive modules. d.2. Develop skills of self-learning using textbooks and journal articles.